Indications |
Intramuscular Pregnancy termination in the 2nd trimester Adult: As tromethamine: 250 mcg deep IM, repeated at 1.5 to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if necessary. Max: 12 mg. Intramuscular Postpartum haemorrhage Adult: As tromethamine: 250 mcg deep IM at 15- to 90-min intervals. Max Dosage: 2 mg. |
Contraindications |
Hypersensitivity. Acute pelvic inflammatory disease. Patients with acute cardiac, pulmonary, renal or hepatic disease. History of caesarian, major uterine surgery. Pregnancy. |
Warnings / Precautions |
Cardiopulmonary disorders, glaucoma, asthma, epilepsy, severe hepatic or renal dysfunction, labour. |
Adverse Reactions |
Nausea, vomiting, diarrhoea, abdominal pain, flushing, shivering, headache, dizziness and hypotension, temporary pyrexia, dyspnoea, pulmonary oedema. Potentially Fatal: Severe CVS disorders including fatal hypotension, tachypnea, pyrexia and MI (in patients with high risk factors) following intra-amniotic or intravaginal admin. Convulsions and ECG changes, amniotic fluid embolism and uterine rupture, foetal distress and rarely foetal death during induction of labour. |
Drug Interactions |
Action enhanced by prior inj of hyperosmolar urea. Potentially Fatal: Enhances action of oxytocin hence both drugs should be used sequentially and carefully monitored. See Below for More carboprost Drug Interactions |
Mechanism of Actions |
Carboprost is a uterine stimulant which results in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental hemostasis. |
Storage Conditions |
Intramuscular: Refrigerate at 2-8°C. |
ATC Classification |
G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site. |
Storage |
Intramuscular: Refrigerate at 2-8°C. |
Available As |
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Carboprost
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Carboprost Containing Brands
Carboprost is used in following diseases
Drug - Drug Interactions of Carboprost
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