Carboprost

Indications
Intramuscular
Pregnancy termination in the 2nd trimester
Adult: As tromethamine: 250 mcg deep IM, repeated at 1.5 to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if necessary. Max: 12 mg.
Intramuscular
Postpartum haemorrhage
Adult: As tromethamine: 250 mcg deep IM at 15- to 90-min intervals.
Max Dosage: 2 mg.
Contraindications
Hypersensitivity. Acute pelvic inflammatory disease. Patients with acute cardiac, pulmonary, renal or hepatic disease. History of caesarian, major uterine surgery. Pregnancy.
Warnings / Precautions
Cardiopulmonary disorders, glaucoma, asthma, epilepsy, severe hepatic or renal dysfunction, labour.
Adverse Reactions
Nausea, vomiting, diarrhoea, abdominal pain, flushing, shivering, headache, dizziness and hypotension, temporary pyrexia, dyspnoea, pulmonary oedema.
Potentially Fatal: Severe CVS disorders including fatal hypotension, tachypnea, pyrexia and MI (in patients with high risk factors) following intra-amniotic or intravaginal admin. Convulsions and ECG changes, amniotic fluid embolism and uterine rupture, foetal distress and rarely foetal death during induction of labour.
Drug Interactions
Action enhanced by prior inj of hyperosmolar urea.
Potentially Fatal: Enhances action of oxytocin hence both drugs should be used sequentially and carefully monitored.
See Below for More carboprost Drug Interactions
Mechanism of Actions
Carboprost is a uterine stimulant which results in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental hemostasis.
Storage Conditions
Intramuscular: Refrigerate at 2-8°C.
ATC Classification
G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Storage
Intramuscular: Refrigerate at 2-8°C.
Available As
  • Carboprost 125 mcg
  • Carboprost 125 mg
  • Carboprost 250 mcg
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