Capreomycin

Indications
 Parenteral
Tuberculosis
Adult: 1 g daily by deep IM or IV Inj for 2-4 mth, then 2-3 times per wk for the remainder of therapy. Max: 20 mg/kg/day.
Child: and infants: 15-30 mg/kg daily. Max: 1 g/day.
Renal impairment: Dose reduction may be needed.

Special Populations: Renal impairment: Adjust dose based on creatinine clearance.
Contraindications
 Hypersensitivity.
Warnings / Precautions
 Renal impairment; when given with other anti-TB drugs, pregnancy, lactation, childn, ototoxicity, hypokalaemia. Audiometry and vestibular tests should be conducted at the start of and at regular intervals during treatment.
Adverse Reactions
 Toxic nephritis, electrolyte disturbances resembling Bartter's syndrome may occur, hearing loss, tinnitus, vertigo, hepatic impairment, leukocytosis or leukopenia, urticaria, maculopapular skin rashes associated with febrile reactions, pain and bleeding at Injection site, sterile abscesses.
Drug Interactions
 Co-admin with aminoglycosides may increase the risk of ototoxicity, resp paralysis and renal dysfunction. Increased risk of nephrotoxicity and ototoxicity with cisplatin and vancomycin. Concurrent colistin increases the risk of nephrotoxicity.
See Below for More capreomycin Drug Interactions
Mechanism of Actions
 Capreomycin is a cyclic polypeptide antimicrobial. It is bacteriostatic against various Mycobacteria, particularly those that have become resistant to primary anti-TB drugs.
Absorption: Poor absorption from GI tract.
Excretion: About 50% of a dose is removed unchanged by glomerular filtration within 12 hr.
Storage Conditions
 Parenteral: Store at 15-30°C.
ATC Classification
 J04AB30 - capreomycin ; Belongs to the class of antibiotics. Used in the systemic treatment of tuberculosis.
Storage
 Parenteral: Store at 15-30°C.
Available As
  • Capreomycin 1000 mg
  • Capreomycin 500 mg
  • Capreomycin 750 mg

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