Indications |
Intravenous Hypocalcaemia and calcium deficiency states Adult: 10-25 mmol at intervals of 1-3 days, adjusted according to patient's needs and serum Ca readings. Ca chloride is given via slow iv at rate not exceeding 1 ml/min(10% solution). Intravenous Severe acute hypocalcaemia Adult: 2.25 mmol by slow IV Inj repeated as required, or followed by 9 mmol/day as continuous IV infusion. Intravenous Hypocalcaemic tetany Adult: 2.25 mmol by slow IV Inj repeated as required, or followed by 9 mmol/day as continuous IV infusion. Intravenous Severe hyperkalaemia Adult: 5-10 ml of 10% solution, to be given over 2-5 min. May be repeated as necessary with ECG monitoring. Child: 20 mg/kg, repeated every 10 min if needed. Intravenous Antidote in severe hypermagnesaemia Adult: 5-10 ml of 10% solution, to be given over 2-5 min. May be repeated as necessary with ECG monitoring. Child: 20 mg/kg, repeated every 10 min if needed. |
Contraindications |
Treatment of hypocalcaemia caused by renal insufficiency or in patients with resp acidosis or failure. Patients with Ca renal calculi or a history renal calculi; IM/SC administration. Parenteral therapy for patients receiving cardiac glycosides. |
Warnings / Precautions |
Impaired renal function; cardiac disease; hypercalcaemia-associated diseases, eg, sarcoidosis; other malignancies. Pregnancy. |
Adverse Reactions |
GI irritation: Soft-tissue calcification, skin sloughing or necrosis after IM/SC injection. Hypercalcaemia characterised by anorexia, nausea, vomiting, constipation, abdominal pain, muscle weakness, mental disturbances, polydipsia, polyuria, nephrocalcinosis, renal calculi; chalky taste, hot flushes and peripheral vasodilation. Potentially Fatal: Cardiac arrhythmias and coma. |
Drug Interactions |
Co-administration of high Ca doses with thiazide diuretics may result in milk-alkali syndrome and hypercalcaemia. May potentiate digoxin toxicity. Decreases effects of calcium-channel blockers. Enhanced absorption with calcitriol (a vit D metabolite). See Below for More calcium chloride Drug Interactions |
Mechanism of Actions |
Calcium chloride is used to prevent or treat negative calcium balance. It also regulates action potential excitation threshold to facilitate nerve and muscle performance. Absorption: Soluble calcium is predominantly absorbed from the small intestine by active transport and passive diffusion. Small intestines by active transport and passive diffusion. There is increased absorption in calcium deficiency states and during childhood, pregnancy and lactation. Distribution: Crosses the placenta and enters breast milk. Excretion: Excreted mainly in the kidneys (as excess calcium), faeces (as unabsorbed calcium) with traces found in sweat, skin, hair and nails. |
Storage Conditions |
Intravenous: Store at 15-30°C. |
ATC Classification |
G04BA03 - calcium chloride ; Belongs to the class of acidifiers. Used in the treatment of urological problems. A12AA07 - calcium chloride ; Belongs to the class of calcium-containing preparations. Used as dietary supplements. B05XA07 - calcium chloride ; Belongs to the class of electrolyte solutions used in I.V. solutions. |
Storage |
Intravenous: Store at 15-30°C. |
Available As |
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Calcium Chloride
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Calcium Chloride Containing Brands
Calcium Chloride is used in following diseases
Drug - Drug Interactions of Calcium Chloride
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