Indications |
Oral Short-term management of anxiety Adult: Initially, 5 mg bid/tid increased by 5-mg increments at intervals of 2-3 days. Max: 45 mg daily in divided doses. Max Dosage: 45 mg daily in divided doses. |
Contraindications |
Hypersensitivity. Epilepsy; severe renal or hepatic impairment; children <18 yr; pregnancy, lactation. |
Warnings / Precautions |
Preceding co-administration of MAOIs, decreased hepatic or renal function. In patients on benzodiazepines, withdraw the drug gradually. May impair ability to drive or operate machinery. |
Adverse Reactions |
Dizziness, nausea, headache, nervousness, lightheadedness, excitement, paraesthesia, sleep disturbances, chest pain, tinnitus, nasal congestion, sore throat. Less sedation and lower potential for dependence compared to other anxiolytics. |
Drug Interactions |
Enhanced sedative effects with alcohol or CNS depressants. Increases serum haloperidol. Concurrent admin with MAOIs may lead to increase in BP. Potentially Fatal: Elevation of BP when taken concomitantly with MAOIs. See Below for More buspirone Drug Interactions |
Mechanism of Actions |
Buspirone exerts anxiolytic activity through high affinity for serotonin 5-HT1A and 5-HT2 receptors. It has moderate affinity for dopamine D2-receptors but no affinity for GABA receptors. Absorption: Rapidly absorbed from the GI tract (oral); peak plasma concentrations after 40-90 minutes. Distribution: Protein-binding: 95%. Metabolism: Extensively hepatic via hydroxylation and oxidative dealkylation. Excretion: Urine and faeces (as metabolites); 2-4 hr (elimination half-life). |
Administration |
May be taken with or without food. (Take consistently either always w/ or always w/o meals.) |
Storage Conditions |
Oral: Store at 15-30°C. |
ATC Classification |
N05BE01 - buspirone ; Belongs to the class of azaspirodecanedione derivatives anxiolytics. Used in the management of anxiety, agitation or tension. |
Storage |
Oral: Store at 15-30°C. |
Available As |
|
Buspirone
Post Review about Buspirone Click here to cancel reply.
Buspirone Containing Brands
Buspirone is used in following diseases
Drug - Drug Interactions of Buspirone
Latest News
- FDA approves Ruconest for treatment of hereditary angioedema
- FDA recommend against aspirin to prevent First Heart Attacks
- FDA approves Pomalyst (pomalidomide) for advanced multiple myeloma
- FDA approves three new drug treatments for type 2 diabetes
- Long-term consequences of vaginal delivery on the pelvic floor
No comments yet.