Buspirone

Indications
Oral
Short-term management of anxiety
Adult: Initially, 5 mg bid/tid increased by 5-mg increments at intervals of 2-3 days. Max: 45 mg daily in divided doses.
Max Dosage: 45 mg daily in divided doses.
Contraindications
Hypersensitivity. Epilepsy; severe renal or hepatic impairment; children <18 yr; pregnancy, lactation.
Warnings / Precautions
Preceding co-administration of MAOIs, decreased hepatic or renal function. In patients on benzodiazepines, withdraw the drug gradually. May impair ability to drive or operate machinery.
Adverse Reactions
Dizziness, nausea, headache, nervousness, lightheadedness, excitement, paraesthesia, sleep disturbances, chest pain, tinnitus, nasal congestion, sore throat. Less sedation and lower potential for dependence compared to other anxiolytics.
Drug Interactions
Enhanced sedative effects with alcohol or CNS depressants. Increases serum haloperidol. Concurrent admin with MAOIs may lead to increase in BP.
Potentially Fatal: Elevation of BP when taken concomitantly with MAOIs.
See Below for More buspirone Drug Interactions
Mechanism of Actions
Buspirone exerts anxiolytic activity through high affinity for serotonin 5-HT1A and 5-HT2 receptors. It has moderate affinity for dopamine D2-receptors but no affinity for GABA receptors.
Absorption: Rapidly absorbed from the GI tract (oral); peak plasma concentrations after 40-90 minutes.
Distribution: Protein-binding: 95%.
Metabolism: Extensively hepatic via hydroxylation and oxidative dealkylation.
Excretion: Urine and faeces (as metabolites); 2-4 hr (elimination half-life).
Administration
May be taken with or without food. (Take consistently either always w/ or always w/o meals.)
Storage Conditions
Oral: Store at 15-30°C.
ATC Classification
N05BE01 - buspirone ; Belongs to the class of azaspirodecanedione derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Storage
Oral: Store at 15-30°C.
Available As
  • Buspirone 10 mg
  • Buspirone 5 mg
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