Brimonidine Tartrate

Indications
 Ophthalmic
Open-angle glaucoma
Adult: Instill 1 drop of a 0.2% solution bid-tid.
Contraindications
 Hypersensitivity. Patients receiving MAO inhibitor therapy.
Warnings / Precautions
 Patients wearing soft contact lenses should wait for at least 15 min after instilling brimonidine tartrate before inserting soft contact lenses. Renal or hepatic impairment. CV disease. Use with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangitis obliterans. Pregnancy, lactation.
Adverse Reactions
 Oral dryness; ocular hyperaemia, burning and stinging; headache, blurring of vision; foreign body sensation, fatigue or drowsiness; conjunctival follicles, ocular allergic reactions and ocular pruritus. Corneal staining or erosion, photophobia, eyelid erythema, ocular ache and pain, ocular dryness, tearing; upper respiratory symptoms; eyelid oedema, conjunctival oedema, dizziness, blepharitis, ocular irritation; GI symptoms; asthaenia; conjunctival blanching, abnormal vision and muscular pain.
Drug Interactions
 Possibility of an additive or potentiating effect with CNS depressants e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics. Caution when used with β-blockers (ophthalmic and systemic), antihypertensives or cardiac glycosides. TCAs can affect the metabolism and uptake of circulating amines.
See Below for More brimonidine Drug Interactions
Mechanism of Actions
 Brimonidine is an α2-adrenoceptor agonist which works to reduce aqueous humor production and increase uveoscleral flow.
Storage Conditions
 Ophthalmic: Store at 15-25°C.
ATC Classification
 S01EA05 - brimonidine ; Belongs to the class of sympathomimetics used in the treatment of glaucoma.
Storage
 Ophthalmic: Store at 15-25°C.
Available As
  • Brimonidine Tartrate 0.10% w/v
  • Brimonidine Tartrate 0.15%
  • Brimonidine Tartrate 0.15% w/v
  • Brimonidine Tartrate 0.2%
  • Brimonidine Tartrate 0.2% w/v
  • Brimonidine Tartrate 1.5 mg
  • Brimonidine Tartrate 2 mg

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