Bisacodyl

Indications
Oral
Constipation
Adult: 5-10 mg at night.
Child: >4 yr: 5 mg at night time.
Elderly:
Oral
Bowel evacuation
Adult: Initially, 10-20 mg the night before the procedure followed by 10 mg suppository admin rectally the next morning.
Child: >10 yr: Same as adult dose. 4-10 yr: 5 mg the night before the procedure and 5 mg suppository admin rectally the following morning. .
Rectal
Constipation
Adult: 10 mg suppository/enema admin in the morning.
Child: <10 yr: 5 mg in the morning.
Contraindications
Acute surgical abdomen or intestinal obstruction, severe dehydration, faecal impaction, chronic use.
Warnings / Precautions
Swallow the tab whole. Pregnancy; inflammatory bowel disease.
Adverse Reactions
Abdominal discomfort (colic, cramps). Suppositories may cause irritation and proctitis.
Overdose Reactions
Overdosage may result in diarrhoea with excessive loss of water and electrolytes.
Drug Interactions
Do not give antacids or milk within 1 hr of taking the drug (enteric coated).
See Below for More bisacodyl Drug Interactions
Lab Interactions
False urinary glucose levels.
Mechanism of Actions
Bisacodyl acts mainly in the large intestine by increasng its motility to effect bowel evacuation.
Onset: 6-12 hr (oral). 15-60 min (rectal).
Absorption: Minimal from the GI tract (oral, as enteric-coated tablets/suppositories).
Metabolism: Converted to bis(p-hydroxyphenyl)pyridyl-2-methane by intestinal or bacterial enzymes.
Excretion: Faeces; urine (as glucuronide).
Administration
Should be taken on an empty stomach. (Take on an empty stomach for rapid effect. Do not take w/in 1 hr of antacids, milk or other dairy products.)
Storage Conditions
Oral: Store below 25°C. Rectal: Store below 25°C.
ATC Classification
A06AB02 - bisacodyl ; Belongs to the class of contact laxatives.
A06AG02 - bisacodyl ; Belongs to the class of enemas. Used in the treatment of constipation.
Storage
Oral: Store below 25°C. Rectal: Store below 25°C.
Available As
  • Bisacodyl 10 mg
  • Bisacodyl 5 mg
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