Bicalutamide

Indications
Oral
Palliative treatment of advanced prostate cancer
Adult: When used with gonadorelin analogue: Usual dose: 50 mg once daily. May be started with or at least 3 days before starting gonadorelin analogue therapy.
Oral
Monotherapy or adjuvant therapy to surgery or radiotherapy in locally advanced prostatic cancer
Adult: 150 mg once daily.
Contraindications
Hypersensitivity. Females, children. Pregnancy, lactation.
Warnings / Precautions
Monitor liver function regularly in hepatically impaired patients on prolonged therapy. Monitoring serum levels of Prostate Specific Antigen (PSA) may be useful in evaluating the patient's clincial progress.
Adverse Reactions
Nausea, vomiting, diarrhoea, asthenia, gynaecomastia, breast tenderness, hot flushes, pruritus, dry skin, alopecia, hirsutism, decreased libido, impotence, weight gain; less commonly hypersensitivity reactions including angioneurotic oedema and urticaria, interstitial lung disease; rarely abdominal pain, CV disorders (including angina, heart failure and arrhythmias), depression, dyspepsia, haematuria, cholestasis, jaundice, thrombocytopenia.
Drug Interactions
Enhances effect of coumarin anticoagulants.
See Below for More bicalutamide Drug Interactions
Mechanism of Actions
Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin, thus preventing the growth of normal and malignant prostatic tissue.
Absorption: Well absorbed from the GI tract (oral).
Distribution: Protein-binding: 96%.
Metabolism: Extensively hepatic by oxidation and glucuronidation.
Excretion: Urine and faeces (as metabolites); 6-7 days (elimination half-life of the R-enantiomer).
Administration
May be taken with or without food.
Storage Conditions
Oral: Store below 30°C.
ATC Classification
L02BB03 - bicalutamide ; Belongs to the class of anti-androgens.
Storage
Oral: Store below 30°C.
Available As
  • Bicalutamide 50 mg
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