Indications |
Oral Palliative treatment of advanced prostate cancer Adult: When used with gonadorelin analogue: Usual dose: 50 mg once daily. May be started with or at least 3 days before starting gonadorelin analogue therapy. Oral Monotherapy or adjuvant therapy to surgery or radiotherapy in locally advanced prostatic cancer Adult: 150 mg once daily. |
Contraindications |
Hypersensitivity. Females, children. Pregnancy, lactation. |
Warnings / Precautions |
Monitor liver function regularly in hepatically impaired patients on prolonged therapy. Monitoring serum levels of Prostate Specific Antigen (PSA) may be useful in evaluating the patient's clincial progress. |
Adverse Reactions |
Nausea, vomiting, diarrhoea, asthenia, gynaecomastia, breast tenderness, hot flushes, pruritus, dry skin, alopecia, hirsutism, decreased libido, impotence, weight gain; less commonly hypersensitivity reactions including angioneurotic oedema and urticaria, interstitial lung disease; rarely abdominal pain, CV disorders (including angina, heart failure and arrhythmias), depression, dyspepsia, haematuria, cholestasis, jaundice, thrombocytopenia. |
Drug Interactions |
Enhances effect of coumarin anticoagulants. See Below for More bicalutamide Drug Interactions |
Mechanism of Actions |
Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin, thus preventing the growth of normal and malignant prostatic tissue. Absorption: Well absorbed from the GI tract (oral). Distribution: Protein-binding: 96%. Metabolism: Extensively hepatic by oxidation and glucuronidation. Excretion: Urine and faeces (as metabolites); 6-7 days (elimination half-life of the R-enantiomer). |
Administration |
May be taken with or without food. |
Storage Conditions |
Oral: Store below 30°C. |
ATC Classification |
L02BB03 - bicalutamide ; Belongs to the class of anti-androgens. |
Storage |
Oral: Store below 30°C. |
Available As |
|
Bicalutamide
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Bicalutamide Containing Brands
Bicalutamide is used in following diseases
Drug - Drug Interactions of Bicalutamide
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