Betaxolol

Indications
 Oral
Angina pectoris
Adult: Initially, 10-20 mg once daily. May increase dose to 40 mg/day if necessary after 7-14 days depending on the patient's response.
Elderly: Initial dose of 5-10 mg/day.
Renal impairment: Patients with severe impairment or on dialysis: initially, 5 mg daily. May increase by 5 mg every 2 wk. Max: 20 mg daily.
Oral
Hypertension
Adult: Initially, 10-20 mg once daily. May increase dose to 40 mg/day if necessary after 7-14 days depending on the patient's response.
Elderly: Initial dose of 5-10 mg/day.
Renal impairment: Patients with severe impairment or on dialysis: initially, 5 mg daily. May increase by 5 mg every 2 wk. Max: 20 mg daily.
Ophthalmic
Open-angle glaucoma
Adult: Instil 1 drop of 0.25% or 0.5% solution bid.
Ophthalmic
Ocular hypertension
Adult: Instil 1 drop of 0.25% or 0.5% solution bid.

Special Populations: Reduce dose in patients with severe renal impairment.
Contraindications
 Sinus bradycardia, cardiogenic shock, overt cardiac failure. Pregnancy .
Warnings / Precautions
 Poor cardiac reserve, bronchospastic diseases, DM, renal or hepatic impairment. May mask signs of hyperthyroidism. Gradual withdrawal is recommended. Children. Lactation.
Adverse Reactions
 Topical use in eye: Mild ocular stinging and discomfort, usually transient and well-tolerated. Rarely, decreased corneal sensitivity, erythema, itching, keratitis and photophobia reported; tiredness, fatigue, headache, impotence, sleep disturbances, cold hands and feet, GI upsets, bradycardia especially in elderly.
Overdose Reactions
 May lead to bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia. Stop treatment and observe patient.
Drug Interactions
 May cause mydriasis when used concurrently with epinephrine. Close observation needed when on β-blocker and catecholamine-depleting drugs such as reserpine, due to possible additive effects resulting in hypotension and/or bradycardia. Caution when used concomitantly with adrenergic, psychotropic drugs.
Potentially Fatal: Enhances calcium channel blockers, anaesthetics and clonidine.
See Below for More betaxolol Drug Interactions
Mechanism of Actions
 Betaxolol is a cardioselective β-blocker which has greater affinity for β1-receptors and has little or no effect on β2-receptors. It also causes the reduction of intraocular pressure by decreasing the production of aqueous humor.
Absorption: Completely absorbed from the GI tract and undergoes minimal first pass effect.
Distribution: Protein binding: 50%. Crosses the placenta and distributes into the breast milk.
Excretion: Elimination half-life: about 16-20 hr. Mainly excreted via hepatic metabolism and urinary excretion.
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 15-25°C.
ATC Classification
 C07AB05 - betaxolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
S01ED02 - betaxolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Storage
 Oral: Store at 15-25°C.
Available As
  • Betaxolol 0.25% w/v
  • Betaxolol 0.5%
  • Betaxolol 0.5% w/v
  • Betaxolol 0.5% w/w
  • Betaxolol 0.56% w/v

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Betaxolol


    Betaxolol Containing Brands

    We are Developing Our database, More results coming soon.

    Betaxolol is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Betaxolol

    We are Developing Our database, More results coming soon.