Benidipine

Indications
 Oral
Hypertension
Adult: 2-4 mg once daily increased to 8 mg once daily, if necessary.
Oral
Angina pectoris
Adult: 4 mg bid.
Contraindications
 Pregnancy and lactation.
Warnings / Precautions
 Elderly. In case of dizziness or lightheadedness, advise patients against handling of heavy machines or working at elevated spots. Reduce dosage gradually while withdrawing drug. Liver function tests.
Adverse Reactions
 Palpitation, facial flushing, hot flushes, chest pressure sensation, headache, dizziness, sleepiness, constipation, nausea, abdominal discomfort, oedema, malaise, tinnitus, redness and warm feeling in the fingers, shoulder stiffness, increased frequency of micturition. Hypersensitive reactions e.g. rash and itching. Elevation of SGOT, SGPT, alkaline phosphatase, total bilirubin, creatinine and uric acid.
Drug Interactions
 β-blockers or diuretics may enhance BP control. Serum concentrations of digoxin may be increased. Cimetidine may inhibit benidipine metabolism.
See Below for More benidipine Drug Interactions
Mechanism of Actions
 The vasorelaxant effect of benidipine is due to its affinity towards dihydropyridine binding sites in calcium channels. Binding of benidipine with calcium channels inhibits calcium current. The onset of action is slow, which results in minimal tachycardia or palpitation.
Administration
 Should be taken with food.
ATC Classification
 C08CA15 - benidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Available As
  • Benidipine 4 mg
  • Benidipine 8 mg

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