Artesunate

Indications	Parenteral Falciparum malaria *Adult:* 2.4 mg/kg via IM or IV admin. Repeat 12 hr and 24 hr later, then once daily thereafter. *Child:* 2.4 mg/kg via IM or IV admin. Repeat 12 hr and 24 hr later, then once daily thereafter.
Contraindications	Hypersensitivity.
Warnings / Precautions	Hepatic or renal insufficiency. Pregnancy and lactation.
Adverse Reactions	Transient and reversible reticulocytopaenia, drug fever, rash, bradycardia, transient 1st-degree heart block and reversible elevation of serum transaminases.
Drug Interactions	Antimalarial potentiating action seen with mefloquine, primaquine and tetracycline. Additive effect with chloroquine. Antagonistic effect with pyrimethamine and sulphonamides. See Below for More artesunate Drug Interactions
Mechanism of Actions	Artesunate is a potent and rapidly-acting blood schizontocide derived from the leaves of the chinese herb, Armesia annua. The exact mode of action is not clear but clinical studies have confirmed the effectiveness of artesunate in P. vivax and falciparum malaria. Excretion: Elimination half-life: about 45 min after IV admin.
ATC Classification	P01BE03 - artesunate ; Belongs to the class of artemisinin and derivative antimalarials.
Available As	Artesunate 100 mg Artesunate 1000 mg Artesunate 200 mg Artesunate 2000 mg Artesunate 25 mg Artesunate 250 mg Artesunate 50 mg Artesunate 500 mg Artesunate 60 mg Artesunate 80 mg

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Drug - Drug Interactions of Artesunate

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