Anastrozole

Indications
 Oral
Advanced or locally advanced breast cancer, Adjuvant treatment in early breast cancer
Adult: In postmenopausal women: 1 mg daily. Adjuvant treatment may be continued for up to 5 yr.
Contraindications
 Pregnancy. Hypersensitivity, premenopausal women.
Warnings / Precautions
 Lactation. Moderate or severe hepatic impairment, hyperlipidaemias. Laboratory test for menopause if status is doubtful. Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter.
Adverse Reactions
 Hot flushes, vaginal dryness, vaginal bleeding, hair thinning, anorexia, nausea, vomiting, diarrhoea, headache, arthralgia, bone fractures, rash, oedema, myalgia, fever, weight gain, leucopenia, flu-like syndrome, asthenia, dizziness, drowsiness, abnormal liver enzyme values, thrombophloebitis, anaphylaxis.
Overdose Reactions
 General supportive care, frequent monitoring of vital signs and close observation of the patient are recommended. Vomiting may be induced if patient is alert.
Drug Interactions
 Efficacy decreased by oestrogens. Plasma concentrations decreased by tamoxifen.
See Below for More anastrozole Drug Interactions
Mechanism of Actions
 Anastrozole prevents conversion of androstenedione to estrone and testosterone to oestradiol by inhibiting aromatase, thus leading to significantly reduced serum oestradiol concentrations.
Absorption: Rapidly and almost completely absorbed from the GI tract (oral); peak plasma concentrations after 2 hr. May decrease the rate of absorption with food.
Distribution: Protein-binding: 40%.
Metabolism: Hepatic.
Excretion: Via urine (as metabolites); 50 hr (elimination half-life).
Administration
 May be taken with or without food.
Storage Conditions
 Oral: Store at 20-25°C.
ATC Classification
 L02BG03 - anastrozole ; Belongs to the class of enzyme inhibitors. Used in endocrine therapy.
Storage
 Oral: Store at 20-25°C.
Available As
  • Anastrozole 1 mg

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