Amisulpride

Indications
 Oral
Acute psychosis
Adult: ≥15 yr: 400-800 mg daily in 2 divided doses. Max: 1.2 g daily. For patients with predominantly negative symptoms: 50-300 mg daily.
CrCl (ml/min)Dosage Recommendation
30-60Half the usual dose.
10-30One-third of the usual dose.

Intramuscular
Acute psychosis
Adult: 400 mg daily.
CrCl (ml/min)Dosage Recommendation
30-60Half the usual dose.
10-30One-third of the usual dose.


Special Populations: In renal impairment: Doses to be reduced to 1/2 the normal adult dose for patients with a CrCl (ClCr) of 30-60 mL/min or to 1/3 of the normal adult dose in patients with a ClCr of 10-30 mL/min.
Contraindications
 Pregnancy and lactation, pheochromocytoma, prolactin-dependent tumors. Children <15 yr.
Warnings / Precautions
 Renal impairment, Parkinson's disease, CV disease, history of epilepsy, elderly. May affect performance of skilled tasks. withdraw gradually and closely monitored to avoid relapse. Elderly.
Adverse Reactions
 Weight gain, dizziness, postural hypotension, extrapyramidal symptoms, neuroleptic malignant syndrome. GI disorders and dry mouth. CNS effects. Hyperprolactinaemia (with galactorrhoea, amenorrhoea, gynecomastia, breast pain, sexual dysfunction).
Overdose Reactions
 Symptoms include generalised convulsions, coma, motor restlessness, tachycardia and slight prolongation of the QT interval.
Drug Interactions
 Guanethidine and other adrenergic neuron blockers, antiarrhythmics, antihistamines, antimalarials and cisapride, diuretics, general anaesthetics, hypnotics, anxiolytics and opioids. Metoclopramide may increase the risk of antipsychotic-induced extrapyramidal effects. Avoid alcohol.
See Below for More amisulpride Drug Interactions
Mechanism of Actions
 Amisulpride is a substituted benzamide atypical antipsychotic with general properties similar to those of sulpiride and is reported to have a high affinity for dopamine D2 and D3 receptors.
Absorption: Bioavailability: about 48%.
Distribution: Protein binding: about 16%.
Metabolism: Limited metabolism.
Excretion: Terminal half-life: 12 hr. Mainly excreted unchanged in urine.
Administration
 Should be taken on an empty stomach. (Preferably taken before meals.)
ATC Classification
 N05AL05 - amisulpride ; Belongs to the class of benzamides antipsychotics.
Available As
  • Amisulpride 100 mg
  • Amisulpride 200 mg
  • Amisulpride 300 mg
  • Amisulpride 400 mg
  • Amisulpride 50 mg

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