Aminocaproic Acid

Indications
Oral
Treatment and prophylaxis of haemorrhage
Adult: Initially, 4-5 g, followed by 1-1.25 g every hr for about 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Renal impairment: Dosage reduction may be required.
Oral
Patients with haemophilia undergoing dental extraction
Adult: Initially, 6 g immediately after the procedure, followed by 6 g every 6 hr for up to 10 days.
Intravenous
Treatment and prophylaxis of haemorrhage
Adult: Initially, 4-5 g as a 2% solution over 1 hr followed by a 1 g/hr infusion continued for up to 8 hr or until bleeding has been controlled. Max: 24 g in 24 hr.
Renal impairment: Dosage reduction may be required.

Special Populations: Dose reduction in patients with renal impairment.
Contraindications
Bleeding due to disseminated intravascular coagulation. Rapid IV administration.
Warnings / Precautions
Renal or cardiac disorders. Urinary tract bleeding, haematuria of upper urinary tract origin; veno-occlusive hepatic disease, skeletal myopathy, neonates. Monitor creatinine phosphokinase. Avoid admin with factor IX complex concentrates. Pregnancy and lactation.
Adverse Reactions
Oedema, headache, malaise, allergic and anaphylactic reactions, anaphylaxis, bradycardia, hypotension, peripheral ischaemia, thrombosis, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, coagulation disorder, leukopaenia, thrombocytopaenia, increased CPK, muscle damage, myalgia, myopathy, myositis, rhabdomyolysis, confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope, dyspnoea, nasal congestion, pulmonary embolism, pruritus, rash, tinnitus, decreased vision, watery eyes, increased BUN, dry ejaculation.
Potentially Fatal: Cardiac and hepatic damage.
Overdose Reactions
Symptoms may range from no reaction to transient hypotension or severe acute renal failure resulting in death.
Drug Interactions
Increased risk of hypercoagulability with OC and oestrogens.
See Below for More aminocaproic acid Drug Interactions
Mechanism of Actions
Aminocaproic acid inhibits the action of plasminogen activators and, to a lesser extent, it also has some antiplasmin activity.
Absorption: Absorbed readily from the GI tract (oral); peak plasma concentrations after 2 hr.
Distribution: Distributed widely.
Excretion: Via urine (as unchanged); 2 hr (elimination half-life).
Administration
May be taken with or without food. (May be taken w/ meals to prevent GI upset.)
Storage Conditions
Intravenous: Store at 15-30°C.
ATC Classification
B02AA01 - aminocaproic acid ; Belongs to the class of amino acid antifibrinolytics. Used in the treatment of hemorrhage.
Storage
Intravenous: Store at 15-30°C.
Available As
  • Aminocaproic Acid 250 mg
  • Aminocaproic Acid 500 mg
  • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Aminocaproic Acid


    Aminocaproic Acid Containing Brands

    We are Developing Our database, More results coming soon.

    Aminocaproic Acid is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Aminocaproic Acid

    We are Developing Our database, More results coming soon.