Amiloride

Indications
 Oral
Oedema
Adult: Initially, 5-10 mg daily. Start with 2.5 mg once daily if used with other diuretics or antihypertensives. Max: 20 mg daily.
Renal impairment: Avoid use.
Contraindications
 Hyperkalaemia.
Warnings / Precautions
 DM, elderly, pregnancy and lactation. Discontinue at least 3 days before glucose-tolerance tests are performed. Monitor serum electrolytes regularly.
Adverse Reactions
 Hyperkalaemia; hyponatraemia; GI disturbances; paraesthesia; thirst; dizziness; skin rash; pruritus; weakness; muscle cramps; headache; minor psychiatric or visual changes; orthostatic hypotension.
Overdose Reactions
 May result in dehydration and electrolyte imbalance. Treatment is symptomatic and supportive.
Drug Interactions
 Potassium supplements; other potassium-sparing diuretics; ACE inhibitors, angiotensin II receptor antagonists. Increased risk of nephrotoxicity with NSAIDs. Ciclosporin. Trilostane; other antihypertensives. Severe hyponatraemia with thiazides or chlorpropamide. Reduce ulcer-healing properties of carbenoxolone.
See Below for More amiloride Drug Interactions
Lab Interactions
 Rise in blood-urea-nitrogen concentrations.
Mechanism of Actions
 Amiloride is a weak diuretic which acts mainly on the distal renal tubules. It increases the excretion of sodium and reduces the excretion of potassium. It diminishes kaliuretic effects of other diuretics, and may produce an additional natriuretic effect.
Onset: 2 hr.
Duration: 24 hr.
Absorption: Bioavailability: about 50%.
Excretion: Plasma half-life: 6-9 hr and terminal half-life: about 20 hr or more. Excreted unchanged by the kidneys.
Administration
 Should be taken with food.
Storage Conditions
 Oral: Store at 15-30°C.
ATC Classification
 C03DB01 - amiloride ; Belongs to the class of other potassium-sparing agents. Used as diuretics.
Storage
 Oral: Store at 15-30°C.
Available As
  • Amiloride 2.5 mg
  • Amiloride 5 mg

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