Albendazole

Indications
Oral
Echinococcosis
Adult: >60 kg: 400 mg bid for 28 days; <60 kg: 15 mg/kg daily in 2 divided doses. Max dose: 800 mg daily. For cystic echinococcosis, up to 3 treatment cycles of 28 days each may be given with 14 treatment-free days in between cycles. For alveolar echinococcosis, treatment cycles of 28 days each with 14 treatment-free days in between. Treatment cycles may need to be continued for mth or yr until complete eradication of parasites.
Oral
Neurocysticercosis
Adult: >60 kg: 400 mg bid; <60 kg: 15 mg/kg daily in 2 divided doses for 8-30 days.
Max Dosage: Adult <60 kg: 800 mg daily.
Oral
Enterobiasis
Adult: 400 mg as a single dose.
Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis.
Oral
Ascariasis
Adult: 400 mg as a single dose.
Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis.
Oral
Hookworm infections
Adult: 400 mg as a single dose.
Child: ≥2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose for enterobiasis.
Oral
Strongyloidiasis
Adult: 400 mg once daily or bid for 3 consecutive days, repeated after 3 wk if necessary.
Oral
Giardiasis
Adult: 400 mg daily for 5 days.
Child: 400 mg daily for 5 days.
Contraindications
Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.
Warnings / Precautions
Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.
Adverse Reactions
GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth.
Potentially Fatal: Bone marrow depression.
Overdose Reactions
Symptomatic and supportive measures are advised.
Drug Interactions
Cimetidine increases albendazole metabolism. Serum levels are increased if taken with dexamethasone and praziquantel agent.
See Below for More albendazole Drug Interactions
Mechanism of Actions
Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus).
Absorption: Poorly absorbed from the GI tract (oral).
Distribution: Widely distributed; bile, CSF. Protein-binding: 70%
Metabolism: Extensive hepatic first-pass metabolism; converted to albendazole sulfoxide.
Excretion: Via bile; via urine (small amounts). 8.5 hr (elimination half-life).
Administration
Should be taken with food.
Storage Conditions
Oral: Store at 20-25°C.
ATC Classification
P02CA03 - albendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.
Storage
Oral: Store at 20-25°C.
Available As
  • Albendazole 100 mg
  • Albendazole 125 mg
  • Albendazole 150 mg
  • Albendazole 1500 mg
  • Albendazole 200 mg
  • Albendazole 300 mg
  • Albendazole 400 mg
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    Albendazole Containing Brands

    Click on Prescription information to see Indications ( Uses ), Contraindications, Prescription information of respective Constituents.

    Brand Name Manufacturer Unit/Price Package unit/Price Constituents/Unit
    Tablet Albiz (400 mg) Jarson Pharmaceuticals 1 Tablet
    ₹ 1.20
    24 Tablet
    ₹ 28.80
  • More Information Albendazole 400 mg
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    Tablet Albendazole (400 mg) (Acichem) Acichem Laboratories 1 Tablet
    ₹ 1.20
    10 Tablet
    ₹ 12.00
  • More Information Albendazole 400 mg
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    Tablet Albent (400 mg) Acto Pharmaceuticals Laboratories 1 Tablet
    ₹ 0.99
    10 Tablet
    ₹ 9.90
  • More Information Albendazole 400 mg
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    Tablet Albeda (400+6) Custodian Pharma Private Limited 1 Tablet
    ₹ 1.69
    10 Tablet
    ₹ 16.92
  • More Information Albendazole 400 mg
  • More Information Ivermectin 6 mg
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    Tablet Benle (400 mg) Blue Star Laboratories Pvt Ltd 1 Tablet
    ₹ 1.10
    10 Tablet
    ₹ 11.00
  • More Information Albendazole 400 mg
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    Suspension Banworm (10 ml) Iscon Lifesciences 1 ml
    ₹ 1.55
    10 ml
    ₹ 15.50
  • More Information Albendazole 200 mg
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    Suspension Helben (100 ml) Merit Organics Ltd. 5 ml
    ₹ 1.00
    100 ml
    ₹ 20.00
  • More Information Albendazole 200 mg
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    Tablet Kiraja (400 mg) Medizone 1 Tablet
    ₹ 1.10
    10 Tablet
    ₹ 11.00
  • More Information Albendazole 400 mg
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    Tablet Meczol (400 mg) Mccoy Biotech 1 Tablet
    ₹ 1.40
    100 Tablet
    ₹ 140.00
  • More Information Albendazole 400 mg
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    Tablet SL 400 (400 mg) Fine Kind Drugs & Pharmaceuticals 1 Tablet
    ₹ 0.99
    10 Tablet
    ₹ 9.90
  • More Information Albendazole 400 mg
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    Drug - Drug Interactions of Albendazole
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