Acenocoumarol

Indications
 Oral
Thromboembolic disorders
Adult: 4-12 mg on the 1st day and 4-8 mg on the 2nd day. Maintenance: 1-8 mg daily given in a single dose at the same time everyday.
Contraindications
 Active haemorrhage or risk of serious haemorrhage; severe hypertension; pregnancy.
Warnings / Precautions
 Bleeding disorders; peptic ulcers; severe wounds; cerebrovascular disorders, bacterial endocarditis; renal or hepatic impairment; lactation. Avoid alcohol.
Adverse Reactions
 Alopecia; fever, nausea, vomiting, diarrhoea; skin rash; cholestatic liver damage.
Potentially Fatal: Haemorrhage.
Drug Interactions
 Potentiates hypoglycaemic agents. Bismuth carbonate and Mg reduce absorption. Cimetidine, allopurinol, diuretics and other oral anticoagulants enhance effect. vit K reverses effect.
Potentially Fatal: Potentiated by NSAIDs, amiodarone, antibacterial agents eg, co-trimoxazole, cephalosporins, erythromycin, quinolone antibiotics, chloramphenicol, doxycycline, INH and neomycin. Rifampicin, barbiturates and griseofulvin diminish effect.
See Below for More acenocoumarol Drug Interactions
Food Interactions
 Renal excretion of metabolites is decreased when administered with grapefruit juice.
Mechanism of Actions
 Acenocoumarol inhibits synthesis of vitamin K-dependent coagulation factors VII, IX, X and II including anticoagulant protein C and its cofactor proteins.
Absorption: Readily absorbed from the GI tract.
Distribution: Extensively bound to plasma proteins.
Excretion: Largely in the urine mainly as metabolites. Elimination half-life: 8-11 hr.
Storage Conditions
 Oral: Store at 20-25°C.
ATC Classification
 B01AA07 - acenocoumarol ; Belongs to the class of vitamin K antagonists. Used in the treatment of thrombosis.
Storage
 Oral: Store at 20-25°C.
Available As
  • Acenocoumarol 1 mg
  • Acenocoumarol 2 mg
  • Acenocoumarol 3 mg
  • Acenocoumarol 4 mg

    • Subscribe for latest updates

    Subscribe to our e-mail newsletter to receive updates.

    No comments yet.

    Post Review about Acenocoumarol


    Acenocoumarol Containing Brands

    We are Developing Our database, More results coming soon.

    Acenocoumarol is used in following diseases

    We are Developing Our database, More results coming soon.

    Drug - Drug Interactions of Acenocoumarol

    We are Developing Our database, More results coming soon.